Senescence in chronic allograft nephropathy
نویسندگان
چکیده
منابع مشابه
Senescence in chronic allograft nephropathy.
Despite increasing numbers of patients on dialysis, the numbers of renal transplants performed yearly have remained relatively static. During the last 50 years, there have been many advances in the pharmacology of prevention of organ rejection. However, most patients will suffer from a slow but steady decline in renal function leading to graft loss. The most common cause of long-term graft loss...
متن کاملRethinking chronic allograft nephropathy: the concept of accelerated senescence.
Chronic rejection or chronic allograft nephropathy (CAN) is the major cause of failure of kidney transplants other than patient death, and has been extensively reviewed (1–5). CAN is characterized by functional impairment with nonspecific pathology: tubular atrophy, interstitial fibrosis, and fibrous intimal thickening (FIT) in the arteries, with variable glomerular lesions. The risk of CAN cor...
متن کاملChronic Allograft Nephropathy
Since the first successful kidney transplantation in 1954 between Identical twins, a new modality to treat patients with terminal kidney insufficiency was born. Although the results in the first decades were modest, continuous development has characterized this captivating field. A major advance was the introduction of the new immunosuppressant cyclosporine A in the early 1980s. The fundament o...
متن کاملManagement of chronic allograft nephropathy.
Chronic renal allograft disease remains a leading cause of graft loss. Immunologic and non-immunologic risk factors are related to its development and may be present before or develop after transplantation. Histological evaluation of renal tissue has an important role in the management, especially for the evaluation of immune activity against the graft and toxicity of immunosuppressive drugs. M...
متن کاملCigarette smoking and chronic allograft nephropathy.
BACKGROUND Smoking has been demonstrated to decrease patient and graft survival after kidney transplantation. Data on histological changes associated with smoking in renal allografts are lacking. METHODS Smoking habits before and after renal transplantation were evaluated by questionnaire in 279 patients. A transplant biopsy was performed more than 1 year after transplantation in 76 of them. ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2018
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00195.2016